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Gene: APBB1 (amyloid beta precursor protein binding family B member 1) Homo sapiens
Symbol: APBB1
Name: amyloid beta precursor protein binding family B member 1
Description: Exhibits several functions, including amyloid-beta binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the endoplasmic reticulum; growth cone; and lamellipodium. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding family B member 1; amyloid beta A4 precursor protein-binding, family B, member 1; amyloid-beta A4 precursor protein-binding family B member 1; FE65; MGC:9072; RIR; stat-like protein
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38116,395,124 - 6,419,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,416,355 - 6,440,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,372,931 - 6,397,220 (-)NCBINCBI36hg18NCBI36
Build 34116,372,930 - 6,397,220NCBI
Celera116,535,423 - 6,559,715 (-)NCBI
Cytogenetic Map11p15.4NCBI
HuRef116,075,464 - 6,099,756 (-)NCBIHuRef
CHM1_1116,415,489 - 6,439,838 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on APBB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349313
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.