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Gene: EXOSC10 (exosome component 10) Homo sapiens
Symbol: EXOSC10
Name: exosome component 10
Description: Exhibits 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Localizes to the cytosol; nuclear lumen; and transcriptionally active chromatin; PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 5-fluorouracil; bisphenol A; cyclosporin A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: autoantigen PM-SCL; autoantigen PM/Scl 2; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 2 (100kD); polymyositis/scleroderma autoantigen 2, 100kDa; RRP6; Rrp6p
Mus musculus (house mouse) : Exosc10 (exosome component 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Exosc10 (exosome component 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Exosc10 (exosome component 10)
Pan paniscus (bonobo/pygmy chimpanzee) : EXOSC10 (exosome component 10)
Canis lupus familiaris (dog) : EXOSC10 (exosome component 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Exosc10 (exosome component 10)
Sus scrofa (pig) : EXOSC10 (exosome component 10)
Chlorocebus sabaeus (African green monkey) : EXOSC10 (exosome component 10)
Heterocephalus glaber (naked mole-rat) : Exosc10 (exosome component 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,066,618 - 11,099,869 (-)Ensembl
GRCh38111,066,613 - 11,099,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,126,675 - 11,159,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,049,262 - 11,082,525 (-)NCBINCBI36hg18NCBI36
Build 34111,060,942 - 11,094,204NCBI
Celera110,238,981 - 10,272,253 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,278,176 - 10,311,219 (-)NCBIHuRef
CHM1_1111,114,652 - 11,147,941 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EXOSC10
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349336
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.