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Gene: KDM5C (lysine demethylase 5C) Homo sapiens
Symbol: KDM5C
Name: lysine demethylase 5C
Description: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DXS1272E; histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; jumonji, AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; lysine-specific demethylase 5C; mental retardation, X-linked 13; MRX13; MRXJ; MRXSCJ; MRXSJ; selected cDNA on X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; smcy homolog, x-linked (mouse); XE169
Mus musculus (house mouse) : Kdm5c (lysine (K)-specific demethylase 5C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm5c (lysine demethylase 5C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm5c (lysine demethylase 5C)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM5C (lysine demethylase 5C)
Canis lupus familiaris (dog) : KDM5C (lysine demethylase 5C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm5c (lysine demethylase 5C)
Sus scrofa (pig) : KDM5C (lysine demethylase 5C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X53,176,277 - 53,225,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,220,503 - 53,254,604 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,237,378 - 53,271,329 (-)NCBINCBI36hg18NCBI36
Build 34X53,104,473 - 53,137,625NCBI
CeleraX57,049,741 - 57,083,840 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,285,660 - 50,319,741 (-)NCBIHuRef
CHM1_1X53,210,762 - 53,244,827 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM5C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349337
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.