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Gene: WAS (WASP actin nucleation promoting factor) Homo sapiens
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Symbol: WAS
Name: WASP actin nucleation promoting factor
Description: Exhibits SH3 domain binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including Cdc42 protein signal transduction; positive regulation of nucleobase-containing compound metabolic process; and regulation of actin filament organization. Localizes to several cellular components, including the actin filament; cytosol; and site of double-strand break. Implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: eczema-thrombocytopenia; IMD2; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); WASP; WASPA; Wiskott-Aldrich syndrome; wiskott-Aldrich syndrome protein
Orthologs:
Mus musculus (house mouse) : Was (Wiskott-Aldrich syndrome)  MGI  Alliance
Rattus norvegicus (Norway rat) : Was (WASP actin nucleation promoting factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Was (WASP actin nucleation promoting factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WAS (WASP actin nucleation promoting factor)
Canis lupus familiaris (dog) : WAS (WASP actin nucleation promoting factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Was (WASP actin nucleation promoting factor)
Sus scrofa (pig) : WAS (WASP actin nucleation promoting factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,683,753 - 48,691,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,542,186 - 48,549,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,427,153 - 48,434,759 (+)NCBINCBI36hg18NCBI36
Build 34X48,298,458 - 48,306,065NCBI
CeleraX53,114,189 - 53,121,821 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,204,599 - 46,212,234 (+)NCBIHuRef
CHM1_1X48,573,355 - 48,580,986 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on WAS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349471
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.