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Gene: HSPA1A (heat shock protein family A (Hsp70) member 1A) Homo sapiens
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Description: Exhibits several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including regulation of RNA metabolic process; regulation of microtubule cytoskeleton organization; and regulation of signal transduction. Localizes to several cellular components, including aggresome; microtubule organizing center; and nuclear speck. Colocalizes with COP9 signalosome. Implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and vascular dementia. Biomarker of atherosclerosis; cardiovascular system disease; status epilepticus; systolic heart failure; and visual epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock-induced protein; HEL-S-103; HSP70; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70.2; HSP70I; HSP72; HSPA1; HSPA1B
Mus musculus (house mouse) : Hspa1a (heat shock protein 1A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hspa1a (heat shock protein family A (Hsp70) member 1A)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA1A (heat shock protein family A (Hsp70) member 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1a (heat shock protein family A (Hsp70) member 1A)
Chlorocebus sabaeus (African green monkey) : HSPA1A (heat shock protein family A (Hsp70) member 1A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,782,952 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSPA1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349475
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.