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Gene: RFWD3 (ring finger and WD repeat domain 3) Homo sapiens
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Symbol: RFWD3
Name: ring finger and WD repeat domain 3
Description: Exhibits MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including DNA metabolic process; mitotic G1 DNA damage checkpoint; and regulation of DNA damage checkpoint. Localizes to the nucleoplasm and site of DNA damage. Colocalizes with the site of double-strand break. Implicated in Fanconi anemia; INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase RFWD3; FANCW; FLJ10520; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3; RNF201
Orthologs:
Mus musculus (house mouse) : Rfwd3 (ring finger and WD repeat domain 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rfwd3 (ring finger and WD repeat domain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfwd3 (ring finger and WD repeat domain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RFWD3 (ring finger and WD repeat domain 3)
Canis lupus familiaris (dog) : RFWD3 (ring finger and WD repeat domain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfwd3 (ring finger and WD repeat domain 3)
Sus scrofa (pig) : RFWD3 (ring finger and WD repeat domain 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,621,396 - 74,666,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371674,655,297 - 74,700,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,212,798 - 73,258,280 (-)NCBINCBI36hg18NCBI36
Celera1658,948,218 - 58,993,367 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1660,404,913 - 60,450,359 (-)NCBIHuRef
CHM1_11676,067,246 - 76,112,724 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on RFWD3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349611
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.