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Gene: RFWD3 (ring finger and WD repeat domain 3) Homo sapiens
Symbol: RFWD3
Name: ring finger and WD repeat domain 3
Description: Exhibits MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including DNA metabolic process; mitotic G1 DNA damage checkpoint; and regulation of DNA damage checkpoint. Localizes to the nucleoplasm and site of DNA damage. Colocalizes with the site of double-strand break. Implicated in Fanconi anemia; INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase RFWD3; FANCW; FLJ10520; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3; RNF201
Mus musculus (house mouse) : Rfwd3 (ring finger and WD repeat domain 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rfwd3 (ring finger and WD repeat domain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfwd3 (ring finger and WD repeat domain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RFWD3 (ring finger and WD repeat domain 3)
Canis lupus familiaris (dog) : RFWD3 (ring finger and WD repeat domain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfwd3 (ring finger and WD repeat domain 3)
Sus scrofa (pig) : RFWD3 (ring finger and WD repeat domain 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381674,621,396 - 74,666,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371674,655,297 - 74,700,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,212,798 - 73,258,280 (-)NCBINCBI36hg18NCBI36
Celera1658,948,218 - 58,993,367 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1660,404,913 - 60,450,359 (-)NCBIHuRef
CHM1_11676,067,246 - 76,112,724 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RFWD3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349611
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.