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Gene: HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Homo sapiens
Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
CRRD ID: 1349823
Description: Exhibits several functions, including CD4 receptor binding activity; MHC class II receptor activity; and peptide antigen binding activity. Involved in several processes, including immunoglobulin mediated immune response; positive regulation of cell communication; and regulation of gene expression. Localizes to MHC class II protein complex; bounding membrane of organelle; and external side of plasma membrane. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Biomarker of toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DR-16; DR-8; DR1; DR16; DR5; DR8; DRB1; DRw10; DRw11; DRw8; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DR1B; HLA-DRB; HLA-DRB1*; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1 precursor; MHC class II antigen; MHC class II antigen HLA-DR13; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; SS1
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   MULTSCL5_H   MULTSCL19_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl632,578,769 - 32,589,848 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,578,775 - 32,589,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,546,546 - 32,557,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,654,527 - 32,665,559 (-)NCBINCBI36hg18NCBI36
Build 34632,654,526 - 32,665,559NCBI
Cytogenetic Map6p21.32NCBI
CHM1_1632,549,025 - 32,560,089 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences