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Gene: KLK1 (kallikrein 1) Homo sapiens
Symbol: KLK1
Name: kallikrein 1
Description: Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Localizes to nucleus. Implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glandular kallikrein 1; hK1; kallikrein 1, renal/pancreas/salivary; kallikrein serine protease 1; kallikrein-1; kidney/pancreas/salivary gland kallikrein; Klk6; KLKR; tissue kallikrein
Mus musculus (house mouse) : Klk1 (kallikrein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klk1 (kallikrein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klk1 (kallikrein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KLK1 (kallikrein 1)
Canis lupus familiaris (dog) : KLK1 (kallikrein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klk1 (kallikrein 1)
Sus scrofa (pig) : KLK1 (kallikrein 1)
Chlorocebus sabaeus (African green monkey) : KLK1 (kallikrein 1)
Heterocephalus glaber (naked mole-rat) : Klk1 (kallikrein 1)
more info ...
Related Pseudogenes: KLKP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1950,819,146 - 50,823,787 (-)EnsemblGRCh38hg38GRCh38
GRCh381950,819,146 - 50,823,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371951,322,402 - 51,327,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,014,216 - 56,018,855 (-)NCBINCBI36hg18NCBI36
Build 341956,014,215 - 56,018,855NCBI
Celera1948,373,507 - 48,378,146 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,656,911 - 47,662,085 (-)NCBIHuRef
CHM1_11951,324,194 - 51,328,835 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on KLK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349866
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.