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Gene: KDM4B (lysine demethylase 4B) Homo sapiens
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Symbol: KDM4B
Name: lysine demethylase 4B
Description: Exhibits histone demethylase activity (H3-K36 specific) and histone demethylase activity (H3-K9 specific). Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Localizes to cytosol and nucleoplasm. Implicated in breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer; PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: [histone H3]-trimethyl-L-lysine(9) demethylase 4B; FLJ44906; jmjC domain-containing histone demethylation protein 3B; JMJD2B; jumonji domain containing 2B; jumonji domain-containing protein 2B; KIAA0876; lysine (K)-specific demethylase 4B; lysine-specific demethylase 4B; TDRD14B; tudor domain containing 14B
Orthologs:
Mus musculus (house mouse) : Kdm4b (lysine (K)-specific demethylase 4B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm4b (lysine demethylase 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4b (lysine demethylase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4B (lysine demethylase 4B)
Canis lupus familiaris (dog) : KDM4B (lysine demethylase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4b (lysine demethylase 4B)
Sus scrofa (pig) : KDM4B (lysine demethylase 4B)
Chlorocebus sabaeus (African green monkey) : KDM4B (lysine demethylase 4B)
Heterocephalus glaber (naked mole-rat) : Kdm4b (lysine demethylase 4B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl194,969,113 - 5,153,598 (+)EnsemblGRCh38hg38GRCh38
GRCh38194,969,087 - 5,153,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,969,123 - 5,153,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,920,132 - 5,104,606 (+)NCBINCBI36hg18NCBI36
Celera194,906,316 - 5,091,160 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef194,730,929 - 4,915,533 (+)NCBIHuRef
CHM1_1194,969,172 - 5,153,207 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KDM4B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349901
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.