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Gene: PRAME (preferentially expressed antigen in melanoma) Homo sapiens
Symbol: PRAME
Name: preferentially expressed antigen in melanoma
Description: Exhibits retinoic acid receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of retinoic acid receptor signaling pathway; and negative regulation of transcription, DNA-templated. Localizes to the nucleoplasm and plasma membrane. Implicated in myeloid leukemia. Biomarker of several diseases, including adenocarcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); neuroblastoma; and osteosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 130; CT130; MAPE; melanoma antigen preferentially expressed in tumors; OIP-4; OIP4; opa-interacting protein 4; Opa-interacting protein OIP4; preferentially expressed antigen of melanoma
Mus musculus (house mouse) : Prame (preferentially expressed antigen in melanoma)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prame (preferentially expressed antigen in melanoma)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prame (preferentially expressed antigen in melanoma)
Canis lupus familiaris (dog) : PRAME (preferentially expressed antigen in melanoma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prame (preferentially expressed antigen in melanoma)
Sus scrofa (pig) : PRAME (preferentially expressed antigen in melanoma)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382222,547,696 - 22,559,361 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,890,123 - 22,901,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,220,123 - 21,231,696 (-)NCBINCBI36hg18NCBI36
Build 342221,214,677 - 21,226,104NCBI
Celera226,710,275 - 6,721,853 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,860,683 - 5,871,798 (-)NCBIHuRef
CHM1_12222,902,166 - 22,913,831 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PRAME
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349908
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.