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Gene: PNP (purine nucleoside phosphorylase) Homo sapiens
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Symbol: PNP
Name: purine nucleoside phosphorylase
Description: Exhibits several functions, including phosphate ion binding activity; purine nucleobase binding activity; and purine-nucleoside phosphorylase activity. Involved in several processes, including interleukin-2 secretion; nucleobase-containing small molecule metabolic process; and positive regulation of T cell activation. Localizes to the cytosol. Implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory sperm binding protein Li 156an; FLJ94043; FLJ97288; FLJ97312; HEL-S-156an; inosine phosphorylase; inosine-guanosine phosphorylase; MGC117396; MGC125915; MGC125916; NP; PRO1837; PUNP; purine-nucleoside:orthophosphate ribosyltransferase
Orthologs:
Mus musculus (house mouse) : Pnp2 (purine-nucleoside phosphorylase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pnp (purine nucleoside phosphorylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pnp (purine nucleoside phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PNP (purine nucleoside phosphorylase)
Canis lupus familiaris (dog) : PNP (purine nucleoside phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pnp (purine nucleoside phosphorylase)
Sus scrofa (pig) : PNP (purine nucleoside phosphorylase)
more info ...
Related Pseudogenes: PNPP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1420,468,954 - 20,477,094 (+)Ensembl
GRCh381420,469,406 - 20,477,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371420,937,538 - 20,946,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,007,382 - 20,015,088 (+)NCBINCBI36hg18NCBI36
Build 341420,007,404 - 20,015,039NCBI
Celera14798,688 - 807,315 (+)NCBI
Cytogenetic Map14q11.2NCBI
HuRef141,059,149 - 1,067,777 (+)NCBIHuRef
CHM1_11420,938,918 - 20,947,545 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PNP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349909
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.