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Gene: MIR181B2 (microRNA 181b-2) Homo sapiens
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Symbol: MIR181B2
Name: microRNA 181b-2
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-181b-2; MIRN181B2
Orthologs:
Mus musculus (house mouse) : Mir181b-2 (microRNA 181b-2)  MGI
Rattus norvegicus (Norway rat) : Mir181b2 (microRNA 181b-2)  Alliance
Canis lupus familiaris (dog) : MIR181B-2 (microRNA mir-181b-2)
Sus scrofa (pig) : MIR181B-2 (microRNA mir-181b-2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,693,710 - 124,693,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379127,455,989 - 127,456,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,495,809 - 126,495,897 (+)NCBINCBI36hg18NCBI36
Celera998,103,875 - 98,103,963 (+)NCBI
Cytogenetic Map9q33.3NCBI
HuRef997,068,713 - 97,068,801 (+)NCBIHuRef
CHM1_19127,604,858 - 127,604,946 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR181B2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349974
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.