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Gene: RPA4 (replication protein A4) Homo sapiens
Symbol: RPA4
Name: replication protein A4
Description: This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HSU24186; MGC120333; MGC120334; replication factor A protein 4; replication protein A 30 kDa subunit; replication protein A complex 34 kd subunit homolog Rpa4; replication protein A4, 30kDa; replication protein A4, 34kDa; RF-A protein 4; RP-A p30
Chinchilla lanigera (long-tailed chinchilla) : Rpa4 (replication protein A4)
Pan paniscus (bonobo/pygmy chimpanzee) : RPA4 (replication protein A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X96,883,908 - 96,885,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X96,138,907 - 96,140,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X96,025,563 - 96,027,122 (+)NCBINCBI36hg18NCBI36
Build 34X95,945,051 - 95,946,593NCBI
CeleraX96,657,000 - 96,658,559 (+)NCBI
Cytogenetic MapXq21.33NCBI
HuRefX85,939,758 - 85,941,283 (+)NCBIHuRef
CHM1_1X96,031,591 - 96,033,150 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RPA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350001
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.