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Gene: SRSF1 (serine and arginine rich splicing factor 1) Homo sapiens
Symbol: SRSF1
Name: serine and arginine rich splicing factor 1
Description: Exhibits DNA topoisomerase binding activity and mRNA binding activity. Involved in alternative mRNA splicing, via spliceosome and mRNA 5'-splice site recognition. Localizes to catalytic step 2 spliceosome; cytoplasm; and nuclear speck. Colocalizes with exon-exon junction complex. Biomarker of several diseases, including cervix uteri carcinoma in situ; clear cell renal cell carcinoma; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and myeloid leukemia (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alternative-splicing factor 1; ASF; ASF-1; FLJ53078; MGC5228; pre-mRNA-splicing factor SF2, P33 subunit; serine/arginine-rich splicing factor 1; SF2; SF2p33; SFRS1; splicing factor 2; splicing factor, arginine/serine-rich 1; splicing factor, arginine/serine-rich, 30-KD, A; SR splicing factor 1; SRp30a
Mus musculus (house mouse) : Srsf1 (serine and arginine-rich splicing factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Srsf1 (serine and arginine rich splicing factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srsf1 (serine and arginine rich splicing factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SRSF1 (serine and arginine rich splicing factor 1)
Canis lupus familiaris (dog) : SRSF1 (serine and arginine rich splicing factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srsf1 (serine and arginine rich splicing factor 1)
Sus scrofa (pig) : SRSF1 (serine and arginine rich splicing factor 1)
Chlorocebus sabaeus (African green monkey) : SRSF1 (serine and arginine rich splicing factor 1)
more info ...
Related Pseudogenes: SRSF1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1758,000,919 - 58,007,346 (-)EnsemblGRCh38hg38GRCh38
GRCh381758,000,919 - 58,007,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371756,078,280 - 56,084,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,433,279 - 53,439,706 (-)NCBINCBI36hg18NCBI36
Build 341753,435,853 - 53,439,587NCBI
Celera1752,540,069 - 52,546,497 (-)NCBI
Cytogenetic Map17q22NCBI
HuRef1751,439,237 - 51,445,664 (-)NCBIHuRef
CHM1_11756,143,411 - 56,149,838 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SRSF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350049
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.