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Gene: HHLA2 (HERV-H LTR-associating 2) Homo sapiens
Symbol: HHLA2
Name: HERV-H LTR-associating 2
Description: Predicted to have signaling receptor binding activity. Involved in T cell costimulation; positive regulation of activated T cell proliferation; and positive regulation of cytokine production. Predicted to localize to external side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B7-H5; B7-H7; B7H7; B7y; HERV-H LTR-associating protein 2; human endogenous retrovirus-H long terminal repeat-associating protein 2
Mus musculus (house mouse) : Gm35938 (predicted gene, 35938)  MGI
Rattus norvegicus (Norway rat) : Hhla2 (HERV-H LTR-associating 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hhla2 (HERV-H LTR-associating 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HHLA2 (HERV-H LTR-associating 2)
Canis lupus familiaris (dog) : HHLA2 (HERV-H LTR-associating 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hhla2 (HERV-H LTR-associating 2)
Sus scrofa (pig) : HHLA2 (HERV-H LTR-associating 2)
Chlorocebus sabaeus (African green monkey) : HHLA2 (HERV-H LTR-associating 2)
Heterocephalus glaber (naked mole-rat) : Hhla2 (HERV-H LTR-associating 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3108,296,490 - 108,378,285 (+)EnsemblGRCh38hg38GRCh38
GRCh383108,296,490 - 108,378,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373108,015,353 - 108,097,132 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,504,022 - 109,579,816 (+)NCBINCBI36hg18NCBI36
Build 343109,504,021 - 109,579,815NCBI
Celera3106,417,960 - 106,493,752 (+)NCBI
Cytogenetic Map3q13.13NCBI
HuRef3105,394,593 - 105,470,415 (+)NCBIHuRef
CHM1_13107,979,484 - 108,061,294 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HHLA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350112
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.