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Gene: PRRG1 (proline rich and Gla domain 1) Homo sapiens
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Symbol: PRRG1
Name: proline rich and Gla domain 1
Description: This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PRGP1; proline rich Gla (G-carboxyglutamic acid) 1; proline-rich Gla (G-carboxyglutamic acid) polypeptide 1; transmembrane gamma-carboxyglutamic acid protein 1
Orthologs:
Mus musculus (house mouse) : Prrg1 (proline rich Gla (G-carboxyglutamic acid) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prrg1 (proline rich and Gla domain 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prrg1 (proline rich and Gla domain 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRRG1 (proline rich and Gla domain 1)
Canis lupus familiaris (dog) : PRRG1 (proline rich and Gla domain 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prrg1 (proline rich and Gla domain 1)
Sus scrofa (pig) : PRRG1 (proline rich and Gla domain 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,349,275 - 37,457,295 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X37,208,528 - 37,316,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,130,773 - 37,201,463 (+)NCBINCBI36hg18NCBI36
Build 34X36,964,818 - 37,072,736NCBI
CeleraX41,346,185 - 41,454,238 (+)NCBI
Cytogenetic MapXp21.1NCBI
HuRefX34,955,127 - 35,062,967 (+)NCBIHuRef
CHM1_1X37,239,598 - 37,347,627 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PRRG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350141
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.