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Gene: UBQLN2 (ubiquilin 2) Homo sapiens
Symbol: UBQLN2
Name: ubiquilin 2
CRRD ID: 1350173
Description: Exhibits identical protein binding activity. Involved in negative regulation of receptor-mediated endocytosis; regulation of cellular catabolic process; and ubiquitin-dependent ERAD pathway. Localizes to cytosol and plasma membrane. Implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS15; CHAP1; CHAP1/DSK2; Dsk2; DSK2 homolog; FLJ10167; FLJ56541; hPLIC-2; HRIHFB2157; LIC-2; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; protein linking IAP with cytoskeleton 2; RIHFB2157; ubiquilin-2; ubiquitin-like product Chap1/Dsk2
Mus musculus (house mouse) : Ubqln2 (ubiquilin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ubqln2 (ubiquilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ubqln2 (ubiquilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UBQLN2 (ubiquilin 2)
Canis lupus familiaris (dog) : UBQLN2 (ubiquilin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ubqln2 (ubiquilin 2)
Sus scrofa (pig) : UBQLN2 (ubiquilin 2)
Chlorocebus sabaeus (African green monkey) : UBQLN2 (ubiquilin 2)
Heterocephalus glaber (naked mole-rat) : Ubqln2 (ubiquilin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX56,563,639 - 56,567,868 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX56,563,627 - 56,567,868 (+)EnsemblGRCh38hg38GRCh38
GRCh38X56,563,627 - 56,567,868 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X56,590,025 - 56,593,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X56,606,797 - 56,610,102 (+)NCBINCBI36hg18NCBI36
Build 34X56,473,092 - 56,476,398NCBI
CeleraX60,422,310 - 60,425,727 (+)NCBI
Cytogenetic MapXp11.21NCBI
HuRefX53,642,196 - 53,645,647 (+)NCBIHuRef
CHM1_1X56,580,226 - 56,583,643 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on UBQLN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350173
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.