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Gene: UBQLN2 (ubiquilin 2) Homo sapiens
Symbol: UBQLN2
Name: ubiquilin 2
Description: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS15; CHAP1; CHAP1/DSK2; Dsk2; DSK2 homolog; FLJ10167; FLJ56541; hPLIC-2; HRIHFB2157; LIC-2; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; protein linking IAP with cytoskeleton 2; RIHFB2157; ubiquilin-2; ubiquitin-like product Chap1/Dsk2
Mus musculus (house mouse) : Ubqln2 (ubiquilin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ubqln2 (ubiquilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ubqln2 (ubiquilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UBQLN2 (ubiquilin 2)
Canis lupus familiaris (dog) : UBQLN2 (ubiquilin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ubqln2 (ubiquilin 2)
Sus scrofa (pig) : UBQLN2 (ubiquilin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X56,563,593 - 56,567,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X56,590,025 - 56,593,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X56,606,797 - 56,610,102 (+)NCBINCBI36hg18NCBI36
Build 34X56,473,092 - 56,476,398NCBI
CeleraX60,422,310 - 60,425,727 (+)NCBI
Cytogenetic MapXp11.21NCBI
HuRefX53,642,196 - 53,645,647 (+)NCBIHuRef
CHM1_1X56,580,226 - 56,583,643 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on UBQLN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350173
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.