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Gene: DOCK4 (dedicator of cytokinesis 4) Homo sapiens
Symbol: DOCK4
Name: dedicator of cytokinesis 4
Description: Exhibits GTPase activator activity; PDZ domain binding activity; and enzyme binding activity. Involved in cell chemotaxis; negative regulation of vascular smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including the Golgi apparatus; cytosol; and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912
Mus musculus (house mouse) : Dock4 (dedicator of cytokinesis 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock4 (dedicator of cytokinesis 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock4 (dedicator of cytokinesis 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK4 (dedicator of cytokinesis 4)
Canis lupus familiaris (dog) : DOCK4 (dedicator of cytokinesis 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock4 (dedicator of cytokinesis 4)
Sus scrofa (pig) : DOCK4 (dedicator of cytokinesis 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387111,726,110 - 112,206,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377111,366,164 - 111,846,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367111,153,400 - 111,633,698 (-)NCBINCBI36hg18NCBI36
Build 347110,962,280 - 111,440,144NCBI
Celera7106,178,467 - 106,658,751 (-)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7105,734,071 - 106,214,221 (-)NCBIHuRef
CHM1_17111,300,360 - 111,780,666 (-)NCBICHM1_1
CRA_TCAGchr7v27110,734,721 - 111,215,001 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DOCK4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350295
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.