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Gene: DOCK4 (dedicator of cytokinesis 4) Homo sapiens
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Symbol: DOCK4
Name: dedicator of cytokinesis 4
Description: Exhibits GTPase activator activity; PDZ domain binding activity; and enzyme binding activity. Involved in cell chemotaxis; negative regulation of vascular smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including the Golgi apparatus; cytosol; and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912
Orthologs:
Mus musculus (house mouse) : Dock4 (dedicator of cytokinesis 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock4 (dedicator of cytokinesis 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock4 (dedicator of cytokinesis 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK4 (dedicator of cytokinesis 4)
Canis lupus familiaris (dog) : DOCK4 (dedicator of cytokinesis 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock4 (dedicator of cytokinesis 4)
Sus scrofa (pig) : DOCK4 (dedicator of cytokinesis 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387111,726,110 - 112,206,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377111,366,164 - 111,846,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367111,153,400 - 111,633,698 (-)NCBINCBI36hg18NCBI36
Build 347110,962,280 - 111,440,144NCBI
Celera7106,178,467 - 106,658,751 (-)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7105,734,071 - 106,214,221 (-)NCBIHuRef
CHM1_17111,300,360 - 111,780,666 (-)NCBICHM1_1
CRA_TCAGchr7v27110,734,721 - 111,215,001 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DOCK4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350295
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.