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Gene: ESX1 (ESX homeobox 1) Homo sapiens
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Symbol: ESX1
Name: ESX homeobox 1
Description: This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ESX1-related protein; ESX1L; ESXR1; extraembryonic, spermatogenesis, homeobox 1 homolog; extraembryonic, spermatogenesis, homeobox 1-like; homeobox protein ESX1
Orthologs:
Mus musculus (house mouse) : Esx1 (extraembryonic, spermatogenesis, homeobox 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Esx1 (ESX homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Esx1 (ESX homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ESX1 (ESX homeobox 1)
Canis lupus familiaris (dog) : ESX1 (ESX homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Esx1 (ESX homeobox 1)
Sus scrofa (pig) : ESX1 (ESX homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X104,250,038 - 104,254,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X103,494,719 - 103,499,599 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X103,381,375 - 103,386,244 (-)NCBINCBI36hg18NCBI36
Build 34X103,300,864 - 103,305,733NCBI
CeleraX103,969,308 - 103,974,187 (-)NCBI
Cytogenetic MapXq22.2NCBI
HuRefX93,122,628 - 93,127,081 (-)NCBIHuRef
CHM1_1X103,405,584 - 103,410,463 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ESX1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350335
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.