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Gene: MMP12 (matrix metallopeptidase 12) Homo sapiens
Symbol: MMP12
Name: matrix metallopeptidase 12
CRRD ID: 1350336
Description: Exhibits several functions, including core promoter sequence-specific DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including elastin catabolic process; negative regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of epithelial cell proliferation involved in wound healing. Localizes to cytoplasm; extracellular space; and nucleus. Implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Biomarker of Marfan syndrome; clear cell renal cell carcinoma; and thoracic aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HME; macrophage elastase; macrophage metalloelastase; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); matrix metalloproteinase-12; ME; MGC138506; MME; MMP-12
Mus musculus (house mouse) : Mmp12 (matrix metallopeptidase 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mmp12 (matrix metallopeptidase 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
Sus scrofa (pig) : MMP12 (matrix metallopeptidase 12)
Chlorocebus sabaeus (African green monkey) : MMP12 (matrix metallopeptidase 12)
Heterocephalus glaber (naked mole-rat) : Mmp12 (matrix metallopeptidase 12)
more info ...
Related Pseudogenes: AC079097.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11102,862,736 - 102,874,982 (-)EnsemblGRCh38hg38GRCh38
GRCh3811102,862,736 - 102,874,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,733,464 - 102,745,764 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,238,674 - 102,250,922 (-)NCBINCBI36hg18NCBI36
Build 3411102,238,685 - 102,250,889NCBI
Celera1199,895,056 - 99,907,358 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,661,485 - 98,673,788 (-)NCBIHuRef
CHM1_111102,616,435 - 102,628,740 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MMP12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350336
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.