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Gene: GREM2 (gremlin 2, DAN family BMP antagonist) Homo sapiens
Symbol: GREM2
Name: gremlin 2, DAN family BMP antagonist
Description: Predicted to have BMP binding activity; heparin binding activity; and receptor ligand activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; embryonic body morphogenesis; and regulation of signal transduction. Predicted to localize to extracellular space. Implicated in tooth agenesis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CKTSF1B2; cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; DAND3; gremlin 2 homolog, cysteine knot superfamily (xenopus laevis); gremlin 2, cysteine knot superfamily, homolog; gremlin-2; PRDC; protein related to DAN and cerberus; STHAG9
Mus musculus (house mouse) : Grem2 (gremlin 2, DAN family BMP antagonist)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grem2 (gremlin 2, DAN family BMP antagonist)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grem2 (gremlin 2, DAN family BMP antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : GREM2 (gremlin 2, DAN family BMP antagonist)
Canis lupus familiaris (dog) : GREM2 (gremlin 2, DAN family BMP antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grem2 (gremlin 2, DAN family BMP antagonist)
Sus scrofa (pig) : GREM2 (gremlin 2, DAN family BMP antagonist)
Chlorocebus sabaeus (African green monkey) : GREM2 (gremlin 2, DAN family BMP antagonist)
Heterocephalus glaber (naked mole-rat) : Grem2 (gremlin 2, DAN family BMP antagonist)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1240,489,573 - 240,612,155 (-)EnsemblGRCh38hg38GRCh38
GRCh381240,489,573 - 240,612,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371240,652,873 - 240,775,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,719,496 - 238,842,085 (-)NCBINCBI36hg18NCBI36
Build 341236,979,833 - 237,101,430NCBI
Celera1213,908,963 - 214,031,592 (-)NCBI
Cytogenetic Map1q43NCBI
HuRef1211,110,745 - 211,233,432 (-)NCBIHuRef
CHM1_11241,924,855 - 242,047,766 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GREM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350364
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.