Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CXCR3 (C-X-C motif chemokine receptor 3) Homo sapiens
Analyze
Symbol: CXCR3
Name: C-X-C motif chemokine receptor 3
Description: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C chemokine receptor type 3; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; chemokine receptor 3; CKR-L2; CMKAR3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; interferon-inducible protein 10 receptor; IP-10 receptor; IP10 receptor; IP10-R; Mig receptor; Mig-R; MigR
Orthologs:
Mus musculus (house mouse) : Cxcr3 (chemokine (C-X-C motif) receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcr3 (C-X-C motif chemokine receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcr3 (C-X-C motif chemokine receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCR3 (C-X-C motif chemokine receptor 3)
Canis lupus familiaris (dog) : CXCR3 (C-X-C motif chemokine receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcr3 (C-X-C motif chemokine receptor 3)
Sus scrofa (pig) : CXCR3 (C-X-C motif chemokine receptor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,615,913 - 71,618,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,835,766 - 70,838,367 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CXCR3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350447
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.