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Gene: CD74 (CD74 molecule) Homo sapiens
Symbol: CD74
Name: CD74 molecule
Description: Exhibits several functions, including MHC class II protein binding, via antigen binding activity groove; amyloid-beta binding activity; and macrophage migration inhibitory factor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of cellular metabolic process; and regulation of signal transduction. Localizes to several cellular components, including cell surface; macrophage migration inhibitory factor receptor complex; and vacuole. Predicted to colocalize with MHC class II protein complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DHLAG; FLJ98970; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLADG; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; II; MHC HLA-DR gamma chain; p33
Mus musculus (house mouse) : Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd74 (CD74 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd74 (CD74 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD74 (CD74 molecule)
Canis lupus familiaris (dog) : CD74 (CD74 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd74 (CD74 molecule)
Sus scrofa (pig) : CD74 (CD74 molecule)
Chlorocebus sabaeus (African green monkey) : CD74 (CD74 molecule)
Heterocephalus glaber (naked mole-rat) : Cd74 (CD74 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5150,400,041 - 150,412,929 (-)EnsemblGRCh38hg38GRCh38
GRCh385150,400,041 - 150,412,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375149,781,200 - 149,792,543 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,761,393 - 149,772,525 (-)NCBINCBI36hg18NCBI36
Build 345149,761,396 - 149,772,511NCBI
Celera5145,862,277 - 145,873,409 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5144,928,781 - 144,940,080 (-)NCBIHuRef
CHM1_15149,213,619 - 149,224,915 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CD74
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350471
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.