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Gene: SRP54 (signal recognition particle 54) Homo sapiens
Symbol: SRP54
Name: signal recognition particle 54
Description: Exhibits several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and purine ribonucleoside binding activity. Contributes to GTPase activity. Involved in protein targeting to ER and response to drug. Localizes to the cytosol; nucleus; and signal recognition particle, endoplasmic reticulum targeting; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: signal recognition particle 54 kDa protein; signal recognition particle 54kD; signal recognition particle 54kDa
Mus musculus (house mouse) : Srp54a (signal recognition particle 54A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Srp54a (signal recognition particle 54A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srp54 (signal recognition particle 54)
Pan paniscus (bonobo/pygmy chimpanzee) : SRP54 (signal recognition particle 54)
Canis lupus familiaris (dog) : SRP54 (signal recognition particle 54)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srp54 (signal recognition particle 54)
Sus scrofa (pig) : SRP54 (signal recognition particle 54)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381434,982,898 - 35,029,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371435,451,901 - 35,498,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,521,982 - 34,568,519 (+)NCBINCBI36hg18NCBI36
Build 341434,521,981 - 34,568,517NCBI
Celera1415,315,912 - 15,362,600 (+)NCBI
Cytogenetic Map14q13.2NCBI
HuRef1415,564,659 - 15,611,702 (+)NCBIHuRef
CHM1_11435,450,690 - 35,497,725 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SRP54
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350478
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.