Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CYBB (cytochrome b-245 beta chain) Homo sapiens
Symbol: CYBB
Name: cytochrome b-245 beta chain
CRRD ID: 1350492
Description: Exhibits flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Contributes to electron transfer activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including innate immune response; respiratory burst; and superoxide anion generation. Localizes to NADPH oxidase complex. Implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Biomarker of renal fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMCBX2; CGD; CGD91-phox; cytochrome b(558) subunit beta; cytochrome b-245 beta polypeptide; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; cytochrome b558 subunit beta; GP91-1; GP91-PHOX; GP91PHOX; heme-binding membrane glycoprotein gp91phox; IMD34; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; p91-PHOX; superoxide-generating NADPH oxidase heavy chain subunit
Mus musculus (house mouse) : Cybb (cytochrome b-245, beta polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cybb (cytochrome b-245 beta chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012042 (cytochrome b-245 heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982531 (cytochrome b-245 heavy chain)
Canis lupus familiaris (dog) : CYBB (cytochrome b-245 beta chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966992 (cytochrome b-245 heavy chain)
Sus scrofa (pig) : GP91-PHOX (NADPH oxidase heavy chain subunit)
Chlorocebus sabaeus (African green monkey) : CYBB (cytochrome b-245 heavy chain)
Heterocephalus glaber (naked mole-rat) : LOC101709509 (cytochrome b-245 heavy chain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX37,780,059 - 37,813,461 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX37,780,011 - 37,813,461 (+)EnsemblGRCh38hg38GRCh38
GRCh38X37,780,059 - 37,813,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X37,639,266 - 37,672,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,524,264 - 37,557,658 (+)NCBINCBI36hg18NCBI36
Build 34X37,395,536 - 37,428,931NCBI
CeleraX41,776,951 - 41,810,391 (+)NCBI
Cytogenetic MapXp21.1-p11.4NCBI
HuRefX35,383,460 - 35,418,115 (+)NCBIHuRef
CHM1_1X37,670,409 - 37,703,853 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYBB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350492
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.