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Gene: CYBB (cytochrome b-245 beta chain) Homo sapiens
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Symbol: CYBB
Name: cytochrome b-245 beta chain
Description: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMCBX2; CGD; CGD91-phox; cytochrome b(558) subunit beta; cytochrome b-245 beta polypeptide; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; cytochrome b558 subunit beta; GP91-1; GP91-PHOX; GP91PHOX; heme-binding membrane glycoprotein gp91phox; IMD34; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; p91-PHOX; superoxide-generating NADPH oxidase heavy chain subunit
Orthologs:
Mus musculus (house mouse) : Cybb (cytochrome b-245, beta polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cybb (cytochrome b-245 beta chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012042 (cytochrome b-245 heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982531 (cytochrome b-245 heavy chain)
Canis lupus familiaris (dog) : CYBB (cytochrome b-245 beta chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966992 (cytochrome b-245 heavy chain)
Sus scrofa (pig) : GP91-PHOX (NADPH oxidase heavy chain subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,780,059 - 37,813,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X37,639,266 - 37,672,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,524,264 - 37,557,658 (+)NCBINCBI36hg18NCBI36
Build 34X37,395,536 - 37,428,931NCBI
CeleraX41,776,951 - 41,810,391 (+)NCBI
Cytogenetic MapXp21.1-p11.4NCBI
HuRefX35,383,460 - 35,418,115 (+)NCBIHuRef
CHM1_1X37,670,409 - 37,703,853 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on CYBB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350492
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.