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Gene: SHB (SH2 domain containing adaptor protein B) Homo sapiens
Symbol: SHB
Name: SH2 domain containing adaptor protein B
Description: Exhibits phosphotyrosine residue binding activity. Predicted to be involved in vascular endothelial growth factor receptor signaling pathway. Localizes to the cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm; PARTICIPATES IN platelet-derived growth factor signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; afimoxifene; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bA3J10.2; RP11-3J10.8; SH2 domain-containing adapter protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); Src homology 2 domain containing adaptor protein B
Mus musculus (house mouse) : Shb (src homology 2 domain-containing transforming protein B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shb (SH2 domain containing adaptor protein B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shb (SH2 domain containing adaptor protein B)
Pan paniscus (bonobo/pygmy chimpanzee) : SHB (SH2 domain containing adaptor protein B)
Canis lupus familiaris (dog) : SHB (SH2 domain containing adaptor protein B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shb (SH2 domain containing adaptor protein B)
Sus scrofa (pig) : SHB (SH2 domain containing adaptor protein B)
Chlorocebus sabaeus (green monkey) : SHB (SH2 domain containing adaptor protein B)
Heterocephalus glaber (naked mole-rat) : Shb (SH2 domain containing adaptor protein B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl937,915,898 - 38,069,227 (-)Ensembl
GRCh38937,915,898 - 38,069,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37937,915,895 - 38,069,210 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36937,905,895 - 38,059,210 (-)NCBINCBI36hg18NCBI36
Build 34937,909,613 - 38,059,208NCBI
Celera937,849,067 - 38,002,380 (-)NCBI
Cytogenetic Map9p13.1NCBI
HuRef937,868,289 - 38,021,594 (-)NCBIHuRef
CHM1_1937,917,509 - 38,070,825 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SHB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350494
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.