Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1) Homo sapiens
Analyze
Symbol: NDUFA1
Name: NADH:ubiquinone oxidoreductase subunit A1
Description: The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CI-MWFE; complex I MWFE subunit; complex I-MWFE; MC1DN12; MWFE; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; NADH oxidoreductase subunit MWFE; NADH-ubiquinone oxidoreductase MWFE subunit; NADH:ubiquinone oxidoreductase (complex 1); type I dehydrogenase; ZNF183
Orthologs:
Mus musculus (house mouse) : Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)
Pan paniscus (bonobo/pygmy chimpanzee) : NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1)
Canis lupus familiaris (dog) : NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)
Sus scrofa (pig) : NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,871,771 - 119,876,666 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,005,734 - 119,010,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,889,762 - 118,894,646 (+)NCBINCBI36hg18NCBI36
Build 34X118,787,615 - 118,792,500NCBI
CeleraX119,460,379 - 119,465,274 (+)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,498,851 - 108,503,745 (+)NCBIHuRef
CHM1_1X118,916,809 - 118,921,703 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NDUFA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350497
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.