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Gene: SRSF4 (serine and arginine rich splicing factor 4) Homo sapiens
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Symbol: SRSF4
Name: serine and arginine rich splicing factor 4
Description: Exhibits RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Localizes to nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: pre-mRNA-splicing factor SRP75; serine/arginine-rich splicing factor 4; SFRS4; splicing factor, arginine/serine-rich 4; SR splicing factor 4; SRP001LB; SRP75
Orthologs:
Mus musculus (house mouse) : Srsf4 (serine and arginine-rich splicing factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Srsf4 (serine and arginine rich splicing factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srsf4 (serine and arginine rich splicing factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SRSF4 (serine and arginine rich splicing factor 4)
Canis lupus familiaris (dog) : SRSF4 (serine and arginine rich splicing factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srsf4 (serine and arginine rich splicing factor 4)
Sus scrofa (pig) : SRSF4 (serine and arginine rich splicing factor 4)
Chlorocebus sabaeus (African green monkey) : SRSF4 (serine and arginine rich splicing factor 4)
Heterocephalus glaber (naked mole-rat) : Srsf4 (serine and arginine rich splicing factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl129,147,743 - 29,181,900 (-)EnsemblGRCh38hg38GRCh38
GRCh38129,147,743 - 29,181,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37129,474,250 - 29,508,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,346,946 - 29,380,948 (-)NCBINCBI36hg18NCBI36
Build 34129,294,980 - 29,328,977NCBI
Celera127,870,392 - 27,904,789 (-)NCBI
Cytogenetic Map1p35.3NCBI
HuRef127,726,138 - 27,760,578 (-)NCBIHuRef
CHM1_1129,589,632 - 29,624,036 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SRSF4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350526
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.