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Gene: APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2) Homo sapiens
Symbol: APEX2
Name: apurinic/apyrimidinic endodeoxyribonuclease 2
Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AP endonuclease 2; AP endonuclease XTH2; APE2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX nuclease 2; APEX nuclease-like 2; APEXL2; apurinic-apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; DNA-(apurinic or apyrimidinic site) lyase 2; DNA-apurinic or apyrimidinic site lyase 2; XTH2; ZGRF2; zinc finger, GRF-type containing 2
Mus musculus (house mouse) : Apex2 (apurinic/apyrimidinic endonuclease 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
Canis lupus familiaris (dog) : APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
Sus scrofa (pig) : APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X55,000,323 - 55,007,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X55,026,756 - 55,034,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,043,505 - 55,050,937 (+)NCBINCBI36hg18NCBI36
Build 34X54,909,800 - 54,917,232NCBI
CeleraX58,861,923 - 58,869,355 (+)NCBI
Cytogenetic MapXp11.21NCBI
HuRefX52,077,699 - 52,085,248 (+)NCBIHuRef
CHM1_1X55,016,795 - 55,024,345 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on APEX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350631
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.