Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SPANXC (SPANX family member C) Homo sapiens
Symbol: SPANXC
Name: SPANX family member C
Description: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C; cancer-testis-associated protein CTp11; cancer/testis antigen 11.3; cancer/testis antigen family 11, member 3; cancer/testis-associated protein CTp11; cancer/testis-associated protein of 11 kD; CT11.3; CTp11; nuclear-associated protein SPAN-Xc; Nuclear-associated protein SPAN-Xe; SPAN-Xc protein; SPANX family, member C; SPANX-C; SPANX-E; SPANXE; sperm protein associated with the nucleus on the X chromosome C; Sperm protein associated with the nucleus on the X chromosome E; sperm protein associated with the nucleus, X chromosome, family member C
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X141,241,463 - 141,242,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X140,335,596 - 140,336,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X140,163,262 - 140,164,312 (-)NCBINCBI36hg18NCBI36
Build 34X140,061,116 - 140,062,166NCBI
CeleraX141,072,907 - 141,073,957 (-)NCBI
Cytogenetic MapXq27.2NCBI
CHM1_1X140,246,723 - 140,248,441 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPANXC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350633
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.