Symbol:
HSDL2
Name:
hydroxysteroid dehydrogenase like 2
Description:
Predicted to have oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Localizes to the mitochondrion and peroxisome; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
C9orf99; FLJ25855; hydroxysteroid dehydrogenase-like protein 2; MGC10940; SDR13C1; short chain dehydrogenase/reductase family 13C member 1; short chain dehydrogenase/reductase family 13C, member 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Hsdl2 (hydroxysteroid dehydrogenase like 2) HGNC
EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Hsdl2 (hydroxysteroid dehydrogenase like 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Hsdl2 (hydroxysteroid dehydrogenase like 2) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
HSDL2 (hydroxysteroid dehydrogenase like 2) NCBI
Ortholog
Canis lupus familiaris (dog):
HSDL2 (hydroxysteroid dehydrogenase like 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hsdl2 (hydroxysteroid dehydrogenase like 2) NCBI
Ortholog
Sus scrofa (pig):
HSDL2 (hydroxysteroid dehydrogenase like 2) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Hsdl2 (hydroxysteroid dehydrogenase like 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Hsdl2 (hydroxysteroid dehydrogenase like 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
hsdl2 (hydroxysteroid dehydrogenase like 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
dhs-18
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
CG5590
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
dhs-6
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 9 112,379,909 - 112,472,410 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 9 115,142,189 - 115,234,685 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 9 114,182,172 - 114,274,505 (+) NCBI NCBI36 hg18 NCBI36 Build 34 9 112,221,905 - 112,314,239 NCBI Celera 9 85,641,314 - 85,733,588 (+) NCBI Cytogenetic Map 9 q32 NCBI HuRef 9 84,740,909 - 84,833,213 (+) NCBI HuRef CHM1_1 9 115,288,820 - 115,381,275 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions ISO RGD:1305387 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HSDL2 mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HSDL2 mRNA CTD PMID:22079256 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551494 6480464 Tetrachlorodibenzodioxin results in increased expression of HSDL2 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HSDL2 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1305387 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSDL2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of HSDL2 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1551494 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSDL2 mRNA CTD PMID:19770486 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:19692669 4-hydroxyphenyl retinamide decreases expression ISO RGD:1551494 6480464 Fenretinide results in decreased expression of HSDL2 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine decreases expression EXP 6480464 Decitabine results in decreased expression of HSDL2 mRNA CTD PMID:19194470 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO RGD:1305387 6480464 Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression ISO RGD:1305387 6480464 Propylthiouracil affects the expression of HSDL2 mRNA CTD PMID:19483382 aflatoxin B1 increases expression ISO RGD:1551494 6480464 Aflatoxin B1 results in increased expression of HSDL2 mRNA CTD PMID:19770486 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of HSDL2 mRNA CTD PMID:21934132 amiodarone affects expression ISO RGD:1305387 6480464 Amiodarone affects the expression of HSDL2 mRNA CTD PMID:19483382 azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of HSDL2 mRNA CTD PMID:22623647 benzbromarone affects expression ISO RGD:1305387 6480464 Benzbromarone affects the expression of HSDL2 mRNA CTD PMID:19483382 benzo[a]pyrene increases expression ISO RGD:1551494 6480464 Benzo(a)pyrene results in increased expression of HSDL2 mRNA CTD PMID:19770486 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1551494 6480464 Diethylhexyl Phthalate results in increased expression of HSDL2 mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1551494 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSDL2 mRNA] CTD PMID:19850644 bisphenol A decreases expression ISO RGD:1305387 6480464 bisphenol A results in decreased expression of HSDL2 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:1305387 6480464 bisphenol A affects the expression of HSDL2 mRNA CTD PMID:30903817 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HSDL2 mRNA CTD PMID:30903817 buspirone increases expression ISO RGD:1305387 6480464 Buspirone results in increased expression of HSDL2 mRNA CTD PMID:24136188 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of HSDL2 mRNA CTD PMID:24376830 cisplatin increases expression ISO RGD:1305387 6480464 Cisplatin results in increased expression of HSDL2 mRNA CTD PMID:22023808 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of HSDL2 mRNA CTD PMID:27392435 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of HSDL2 mRNA CTD PMID:27392435 , PMID:27594783 clofibrate affects expression ISO RGD:1305387 6480464 Clofibrate affects the expression of HSDL2 mRNA CTD PMID:19483382 clofibrate increases expression ISO RGD:1551494 6480464 Clofibrate results in increased expression of HSDL2 mRNA CTD PMID:17585979 more ... clofibrate multiple interactions ISO RGD:1551494 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HSDL2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSDL2 mRNA] CTD PMID:17585979 clofibrate increases expression ISO RGD:1305387 6480464 Clofibrate results in increased expression of HSDL2 protein CTD PMID:16470657 cobalt dichloride decreases expression ISO RGD:1305387 6480464 cobaltous chloride results in decreased expression of HSDL2 mRNA CTD PMID:24386269 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of HSDL2 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1551494 6480464 Cyclosporine results in decreased expression of HSDL2 mRNA CTD PMID:19770486 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of HSDL2 mRNA CTD PMID:20106945 more ... decabromodiphenyl ether increases expression ISO RGD:1305387 6480464 decabromobiphenyl ether results in increased expression of HSDL2 mRNA CTD PMID:23640034 decanoyl-CoA multiple interactions EXP 6480464 [decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 dichloroacetic acid increases expression ISO RGD:1551494 6480464 Dichloroacetic Acid results in increased expression of HSDL2 mRNA CTD PMID:28962523 dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of HSDL2 mRNA CTD PMID:28302478 doxorubicin affects response to substance EXP 6480464 HSDL2 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin decreases expression ISO RGD:1551494 6480464 Doxorubicin results in decreased expression of HSDL2 mRNA CTD PMID:26873546 ethanol affects expression ISO RGD:1551494 6480464 Ethanol affects the expression of HSDL2 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of HSDL2 mRNA CTD PMID:23649840 finasteride increases expression ISO RGD:1305387 6480464 Finasteride results in increased expression of HSDL2 mRNA CTD PMID:24136188 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of HSDL2 mRNA CTD PMID:23649840 glafenine decreases expression ISO RGD:1305387 6480464 Glafenine results in decreased expression of HSDL2 mRNA CTD PMID:24136188 GW 501516 multiple interactions EXP 6480464 [GW 501516 binds to PPARD protein] which results in increased expression of HSDL2 mRNA CTD PMID:16197558 hexadecanoic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] affects the expression of HSDL2 mRNA, [Palmitic Acid co-treated with Oleic Acid] results in increased expression of HSDL2 mRNA CTD PMID:30547786 indole-3-methanol multiple interactions ISO RGD:1305387 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of HSDL2 mRNA CTD PMID:22129741 L-ethionine affects expression ISO RGD:1305387 6480464 Ethionine affects the expression of HSDL2 mRNA CTD PMID:19483382 lauroyl-CoA multiple interactions EXP 6480464 [lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 leflunomide increases expression ISO RGD:1305387 6480464 leflunomide results in increased expression of HSDL2 mRNA CTD PMID:24136188 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of HSDL2 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions ISO RGD:1305387 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of HSDL2 mRNA CTD PMID:22129741 NADP zwitterion multiple interactions EXP 6480464 [22-hydroxycholesterol co-treated with NADP] binds to HSDL2 protein more ... CTD PMID:25526675 NADP(+) multiple interactions EXP 6480464 [22-hydroxycholesterol co-treated with NADP] binds to HSDL2 protein more ... CTD PMID:25526675 nefazodone increases expression ISO RGD:1305387 6480464 nefazodone results in increased expression of HSDL2 mRNA CTD PMID:24136188 nimesulide increases expression ISO RGD:1305387 6480464 nimesulide results in increased expression of HSDL2 mRNA CTD PMID:24136188 oleic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] affects the expression of HSDL2 mRNA, [Palmitic Acid co-treated with Oleic Acid] results in increased expression of HSDL2 mRNA CTD PMID:30547786 omeprazole affects expression ISO RGD:1305387 6480464 Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 oxybenzone decreases expression ISO RGD:1305387 6480464 oxybenzone results in decreased expression of HSDL2 mRNA CTD PMID:30316929 paracetamol multiple interactions ISO RGD:1551494 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HSDL2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSDL2 mRNA] CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of HSDL2 mRNA CTD PMID:25704631 pentachlorophenol increases expression ISO RGD:1551494 6480464 Pentachlorophenol results in increased expression of HSDL2 mRNA CTD PMID:23892564 perfluorohexanesulfonic acid increases expression ISO RGD:1551494 6480464 perfluorohexanesulfonic acid results in increased expression of HSDL2 mRNA CTD PMID:28558994 perfluorononanoic acid increases expression ISO RGD:1551494 6480464 perfluorononanoic acid results in increased expression of HSDL2 mRNA CTD PMID:28558994 perfluorooctane-1-sulfonic acid increases expression ISO RGD:1551494 6480464 perfluorooctane sulfonic acid results in increased expression of HSDL2 mRNA CTD PMID:28558994 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:1551494 6480464 PPARA protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of HSDL2 mRNA] CTD PMID:28558994 perfluorooctanoic acid increases expression ISO RGD:1551494 6480464 perfluorooctanoic acid results in increased expression of HSDL2 mRNA CTD PMID:28558994 , PMID:30711707 perfluorooctanoic acid increases expression ISO RGD:1305387 6480464 perfluorooctanoic acid results in increased expression of HSDL2 mRNA CTD PMID:28511854 permethrin increases expression ISO RGD:1551494 6480464 Permethrin results in increased expression of HSDL2 mRNA CTD PMID:30629241 pirinixic acid affects expression ISO RGD:1305387 6480464 pirinixic acid affects the expression of HSDL2 mRNA CTD PMID:19483382 pirinixic acid increases expression ISO RGD:1551494 6480464 pirinixic acid results in increased expression of HSDL2 mRNA CTD PMID:17426115 more ... potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of HSDL2 mRNA CTD PMID:22079256 potassium chromate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HSDL2 mRNA CTD PMID:22079256 pravastatin decreases expression ISO RGD:1551494 6480464 Pravastatin results in decreased expression of HSDL2 mRNA CTD PMID:27225895 pravastatin increases expression ISO RGD:1305387 6480464 Pravastatin results in increased expression of HSDL2 mRNA CTD PMID:27225895 rotenone increases expression ISO RGD:1305387 6480464 Rotenone results in increased expression of HSDL2 mRNA CTD PMID:28374803 tacrolimus hydrate decreases expression ISO RGD:1551494 6480464 Tacrolimus results in decreased expression of HSDL2 mRNA CTD PMID:25270620 Tesaglitazar increases expression ISO RGD:1305387 6480464 tesaglitazar results in increased expression of HSDL2 mRNA CTD PMID:21515302 tetrachloromethane decreases expression ISO RGD:1305387 6480464 Carbon Tetrachloride results in decreased expression of HSDL2 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1305387 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HSDL2 mRNA] CTD PMID:31150632 thioacetamide affects expression ISO RGD:1305387 6480464 Thioacetamide affects the expression of HSDL2 mRNA CTD PMID:19483382 tolcapone increases expression ISO RGD:1305387 6480464 tolcapone results in increased expression of HSDL2 mRNA CTD PMID:24136188 trichloroethene increases expression ISO RGD:1551494 6480464 Trichloroethylene results in increased expression of HSDL2 mRNA CTD PMID:28973375 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of HSDL2 mRNA CTD PMID:24935251 trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of HSDL2 mRNA CTD PMID:28542535 troglitazone increases expression ISO RGD:1305387 6480464 troglitazone results in increased expression of HSDL2 mRNA, troglitazone results in increased expression of HSDL2 protein CTD PMID:21315101 , PMID:21515302 valdecoxib increases expression ISO RGD:1305387 6480464 valdecoxib results in increased expression of HSDL2 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:1551494 6480464 Valproic Acid affects the expression of HSDL2 mRNA CTD PMID:17292431 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of HSDL2 mRNA CTD PMID:23179753 more ... valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of HSDL2 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1551494 6480464 Valproic Acid results in decreased expression of HSDL2 mRNA CTD PMID:21427059 valproic acid increases expression ISO RGD:1551494 6480464 Valproic Acid results in increased expression of HSDL2 mRNA CTD PMID:21427059 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of HSDL2 mRNA CTD PMID:23527032 vinclozolin affects expression ISO RGD:1305387 6480464 vinclozolin affects the expression of HSDL2 mRNA CTD PMID:19015723 zaragozic acid A increases expression ISO RGD:1305387 6480464 squalestatin 1 results in increased expression of HSDL2 mRNA CTD PMID:27225895 zaragozic acid A increases expression ISO RGD:1551494 6480464 squalestatin 1 results in increased expression of HSDL2 mRNA CTD PMID:27225895 
Gene-Chemical Interaction Annotations
