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Gene: ISCA1 (iron-sulfur cluster assembly 1) Homo sapiens
Symbol: ISCA1
Name: iron-sulfur cluster assembly 1
Description: Predicted to have 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to localize to the mitochondrion. Implicated in multiple mitochondrial dysfunctions syndrome 5.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HBLD2; HESB like domain containing 2; HESB-like domain-containing protein 2; hIscA; iron sulfur assembly protein IscA; iron-sulfur assembly protein IscA; iron-sulfur cluster assembly 1 homolog, mitochondrial; ISA1; MGC4276; MMDS5; RP11-507D14.2
Mus musculus (house mouse) : Isca1 (iron-sulfur cluster assembly 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Isca1 (iron-sulfur cluster assembly 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isca1 (iron-sulfur cluster assembly 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISCA1 (iron-sulfur cluster assembly 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isca1 (iron-sulfur cluster assembly 1)
Sus scrofa (pig) : ISCA1 (iron-sulfur cluster assembly 1)
more info ...
Related Pseudogenes: ISCA1P1   ISCA1P2   ISCA1P3   ISCA1P4   ISCA1P5   ISCA1P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38986,264,546 - 86,282,538 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37988,879,461 - 88,897,676 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36988,069,281 - 88,087,310 (-)NCBINCBI36hg18NCBI36
Build 34986,109,015 - 86,127,044NCBI
Celera959,449,572 - 59,467,604 (-)NCBI
Cytogenetic Map9q21.33NCBI
HuRef958,702,212 - 58,720,322 (-)NCBIHuRef
CHM1_1989,025,905 - 89,043,932 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ISCA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350652
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.