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Gene: USP27X (ubiquitin specific peptidase 27 X-linked) Homo sapiens
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Symbol: USP27X
Name: ubiquitin specific peptidase 27 X-linked
Description: This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deubiquitinating enzyme 27; MRX105; ubiquitin carboxyl-terminal hydrolase 22-like; ubiquitin carboxyl-terminal hydrolase 27; ubiquitin specific peptidase 27, X-linked; ubiquitin specific protease 27, X chromosome; ubiquitin thioesterase 27; ubiquitin thiolesterase 27; ubiquitin-specific-processing protease 27; USP22L; USP27; X-linked ubiquitin carboxyl-terminal hydrolase 27
Orthologs:
Mus musculus (house mouse) : Usp27x (ubiquitin specific peptidase 27, X chromosome)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp27x (ubiquitin specific peptidase 27, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp27x (ubiquitin specific peptidase 27 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : USP27X (ubiquitin specific peptidase 27, X-linked)
Canis lupus familiaris (dog) : USP27X (ubiquitin specific peptidase 27 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp27x (ubiquitin specific peptidase 27 X-linked)
Sus scrofa (pig) : USP27X (ubiquitin specific peptidase 27 X-linked)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,879,867 - 49,882,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,644,470 - 49,647,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,530,949 - 49,533,210 (+)NCBINCBI36hg18NCBI36
CeleraX53,713,777 - 53,716,476 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX47,113,635 - 47,116,334 (+)NCBIHuRef
CHM1_1X49,724,245 - 49,726,944 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on USP27X
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350698
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-02
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.