Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon) Homo sapiens
Symbol: YWHAE
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
CRRD ID: 1350802
Description: Exhibits several functions, including enzyme binding activity; ion channel binding activity; and ion channel regulator activity. Involved in several processes, including negative regulation of peptidyl-serine dephosphorylation; positive regulation of protein export from nucleus; and regulation of ion transmembrane transport. Localizes to cytosol and nucleus. Colocalizes with plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; epididymis luminal protein 2; FLJ45465; FLJ53559; HEL2; KCIP-1; MDCR; MDS; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
Related Pseudogenes: LOC100130210   YWHAEP1   YWHAEP2   YWHAEP3   YWHAEP4   YWHAEP5   YWHAEP6   YWHAEP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl171,344,275 - 1,400,222 (-)EnsemblGRCh38hg38GRCh38
GRCh38171,344,275 - 1,400,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37171,247,833 - 1,303,669 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,194,590 - 1,250,267 (-)NCBINCBI36hg18NCBI36
Build 34171,194,594 - 1,250,267NCBI
Celera171,261,362 - 1,317,358 (-)NCBI
Cytogenetic Map17p13.3NCBI
HuRef171,148,526 - 1,204,512 (-)NCBIHuRef
CHM1_1171,256,607 - 1,312,325 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on YWHAE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350802
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.