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Gene: NR0B1 (nuclear receptor subfamily 0 group B member 1) Homo sapiens
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Symbol: NR0B1
Name: nuclear receptor subfamily 0 group B member 1
Description: This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AHC; AHCH; AHX; DAX-1; DAX1; DSS; DSS-AHC critical region on the X chromosome protein 1; GTD; HHG; NROB1; nuclear hormone receptor; nuclear receptor DAX-1; nuclear receptor DAX1; nuclear receptor subfamily 0, group B, member 1; SRXY2; truncated nuclear receptor subfamily 0 group B member 1
Orthologs:
Mus musculus (house mouse) : Nr0b1 (nuclear receptor subfamily 0, group B, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr0b1 (nuclear receptor subfamily 0, group B, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr0b1 (nuclear receptor subfamily 0 group B member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR0B1 (nuclear receptor subfamily 0 group B member 1)
Canis lupus familiaris (dog) : NR0B1 (nuclear receptor subfamily 0 group B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr0b1 (nuclear receptor subfamily 0 group B member 1)
Sus scrofa (pig) : NR0B1 (nuclear receptor subfamily 0 group B member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X30,304,422 - 30,309,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X30,322,539 - 30,327,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,232,506 - 30,237,413 (-)NCBINCBI36hg18NCBI36
Build 34X30,082,242 - 30,087,149NCBI
CeleraX34,444,104 - 34,449,076 (-)NCBI
Cytogenetic MapXp21.2NCBI
HuRefX28,059,200 - 28,064,172 (-)NCBIHuRef
CHM1_1X30,353,361 - 30,358,333 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NR0B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350844
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.