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Gene: KRAS (KRAS proto-oncogene, GTPase) Homo sapiens
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Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Description: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-K-RAS; c-Ki-ras; c-Ki-ras2; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; CFC2; GTPase KRas; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS1; KRAS2; NS; NS3; OES; oncogene KRAS2; PR310 c-K-ras oncogene; RALD; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Kras (Kirsten rat sarcoma viral oncogene homolog)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kras (KRAS proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kras (KRAS proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : KRAS (KRAS proto-oncogene, GTPase)
Canis lupus familiaris (dog) : KRAS (KRAS proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kras (KRAS proto-oncogene, GTPase)
Sus scrofa (pig) : KRAS (KRAS proto-oncogene, GTPase)
more info ...
Related Pseudogenes: KRASP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,205,246 - 25,250,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371225,358,180 - 25,403,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,249,447 - 25,295,121 (-)NCBINCBI36hg18NCBI36
Build 341225,249,446 - 25,295,121NCBI
Celera1230,505,144 - 30,550,804 (-)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1225,128,895 - 25,174,493 (-)NCBIHuRef
CHM1_11225,322,879 - 25,368,990 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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