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Gene: DYM (dymeclin) Homo sapiens
Symbol: DYM
Name: dymeclin
Description: This gene encodes a protein which regulates Golgi-associated secretory pathways that are essential to endochondral bone formation during early development. This gene is also believed to play a role in early brain development. This gene is widely expressed in embryos and is particularly abundant in chodrocytes and brain tissues. It encodes a peripheral membrane protein which shuttles between the cytosol and Golgi complex. Mutations in this gene are associated with two types of recessive osteochondrodysplasia: Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia. [provided by RefSeq, Jun 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DMC; dyggve-Melchior-Clausen syndrome protein; FLJ20071; FLJ90130; SMC
Mus musculus (house mouse) : Dym (dymeclin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dym (dymeclin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dym (dymeclin)
Pan paniscus (bonobo/pygmy chimpanzee) : DYM (dymeclin)
Canis lupus familiaris (dog) : DYM (dymeclin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dym (dymeclin)
Sus scrofa (pig) : DYM (dymeclin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381849,041,474 - 49,460,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371846,567,846 - 46,987,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361844,824,170 - 45,241,077 (-)NCBINCBI36hg18NCBI36
Build 341844,824,169 - 45,241,077NCBI
Celera1843,423,709 - 43,842,456 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1843,422,918 - 43,840,755 (-)NCBIHuRef
CHM1_11846,565,142 - 46,982,392 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DYM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350887
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.