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Gene: FHL2 (four and a half LIM domains 2) Homo sapiens
Symbol: FHL2
Name: four and a half LIM domains 2
Description: Exhibits identical protein binding activity and transcription factor binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of transcription by RNA polymerase II. Localizes to the focal adhesion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAG11; aging-associated gene 11; down-regulated in rhabdomyosarcoma LIM protein; DRAL; FHL-2; four and a half LIM domains protein 2; four and a half LIM-domain protein 2; four-and-a-half LIM domains 2; LIM domain protein DRAL; skeletal muscle LIM-protein 3; SLIM-3; SLIM3
Mus musculus (house mouse) : Fhl2 (four and a half LIM domains 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fhl2 (four and a half LIM domains 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhl2 (four and a half LIM domains 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FHL2 (four and a half LIM domains 2)
Canis lupus familiaris (dog) : FHL2 (four and a half LIM domains 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhl2 (four and a half LIM domains 2)
Sus scrofa (pig) : FHL2 (four and a half LIM domains 2)
Chlorocebus sabaeus (green monkey) : FHL2 (four and a half LIM domains 2)
Heterocephalus glaber (naked mole-rat) : Fhl2 (four and a half LIM domains 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2105,357,712 - 105,438,513 (-)Ensembl
GRCh382105,357,712 - 105,438,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372105,977,272 - 106,055,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,343,715 - 105,421,392 (-)NCBINCBI36hg18NCBI36
Build 342105,435,802 - 105,513,478NCBI
Celera2100,177,732 - 100,255,816 (-)NCBI
Cytogenetic Map2q12.2NCBI
HuRef299,745,771 - 99,823,720 (-)NCBIHuRef
CHM1_12105,981,590 - 106,059,537 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FHL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350947
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.