Gene: SLPI (secretory leukocyte peptidase inhibitor) Homo sapiens
Symbol: SLPI
Name: secretory leukocyte peptidase inhibitor
Description: This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALK1; ALP; antileukoproteinase; BLPI; HUSI; HUSI-1; HUSI-I; MPI; mucus proteinase inhibitor; protease inhibitor WAP4; secretory leukocyte protease inhibitor (antileukoproteinase); seminal proteinase inhibitor; WAP four-disulfide core domain 4; WAP four-disulfide core domain protein 4; WAP4; WFDC4
Mus musculus (house mouse) : Slpi (secretory leukocyte peptidase inhibitor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slpi (secretory leukocyte peptidase inhibitor)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SLPI (secretory leukocyte peptidase inhibitor)
Canis lupus familiaris (dog) : SLPI (secretory leukocyte peptidase inhibitor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slpi (secretory leukocyte peptidase inhibitor)
Sus scrofa (pig) : SLPI (secretory leukocyte peptidase inhibitor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382045,252,239 - 45,254,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,880,880 - 43,883,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,314,293 - 43,316,620 (-)NCBINCBI36hg18NCBI36
Build 342043,314,292 - 43,316,620NCBI
Celera2040,589,481 - 40,591,808 (-)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2040,622,786 - 40,625,111 (-)NCBIHuRef
CHM1_12043,783,432 - 43,785,757 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SLPI
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350976
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-02-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.