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Gene: SFRP4 (secreted frizzled related protein 4) Homo sapiens
Symbol: SFRP4
Name: secreted frizzled related protein 4
CRRD ID: 1350997
Description: Exhibits Wnt-protein binding activity. Involved in several processes, including negative regulation of sodium-dependent phosphate transport; positive regulation of macromolecule metabolic process; and regulation of canonical Wnt signaling pathway. Localizes to several cellular components, including cell surface; extracellular space; and nucleus. Implicated in metaphyseal dysplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: frizzled protein, human endometrium; FRP-4; FRPHE; FRZB-2; MGC26498; PYL; secreted frizzled-related protein 4; sFRP-4
Mus musculus (house mouse) : Sfrp4 (secreted frizzled-related protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sfrp4 (secreted frizzled-related protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sfrp4 (secreted frizzled related protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SFRP4 (secreted frizzled related protein 4)
Canis lupus familiaris (dog) : SFRP4 (secreted frizzled related protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sfrp4 (secreted frizzled related protein 4)
Sus scrofa (pig) : SFRP4 (secreted frizzled related protein 4)
Chlorocebus sabaeus (African green monkey) : SFRP4 (secreted frizzled related protein 4)
Heterocephalus glaber (naked mole-rat) : Sfrp4 (secreted frizzled related protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl737,905,932 - 38,025,695 (-)EnsemblGRCh38hg38GRCh38
GRCh38737,905,932 - 37,916,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37737,945,534 - 37,956,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36737,912,068 - 37,922,902 (-)NCBINCBI36hg18NCBI36
Build 34737,718,782 - 37,729,617NCBI
Celera737,930,244 - 37,941,234 (-)NCBI
Cytogenetic Map7p14.1NCBI
HuRef737,825,879 - 37,836,854 (-)NCBIHuRef
CHM1_1737,945,489 - 37,956,481 (-)NCBICHM1_1
CRA_TCAGchr7v2737,983,430 - 37,994,420 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SFRP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1350997
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.