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Gene: CBX8 (chromobox 8) Homo sapiens
Symbol: CBX8
Name: chromobox 8
Description: Exhibits methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to the PRC1 complex; nuclear chromatin; and nucleoplasm. Biomarker of esophagus squamous cell carcinoma and glioblastoma multiforme; PARTICIPATES IN histone modification pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; arsenite(3-); bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chromobox homolog 8 (Pc class homolog, Drosophila); chromobox protein homolog 8; HPC3; Pc class 3 homolog; PC3; polycomb 3; RC1; rectachrome 1
Mus musculus (house mouse) : Cbx8 (chromobox 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cbx8 (chromobox 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbx8 (chromobox 8)
Pan paniscus (bonobo/pygmy chimpanzee) : CBX8 (chromobox 8)
Canis lupus familiaris (dog) : CBX8 (chromobox 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbx8 (chromobox 8)
Sus scrofa (pig) : CBX8 (chromobox 8)
Chlorocebus sabaeus (African green monkey) : CBX8 (chromobox 8)
Heterocephalus glaber (naked mole-rat) : Cbx8 (chromobox 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1779,792,132 - 79,801,683 (-)Ensembl
GRCh381779,792,132 - 79,797,077 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371777,768,176 - 77,770,915 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361775,382,771 - 75,385,485 (-)NCBINCBI36hg18NCBI36
Build 341775,382,770 - 75,385,485NCBI
Celera1774,393,725 - 74,396,464 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1773,209,049 - 73,211,788 (-)NCBIHuRef
CHM1_11777,854,395 - 77,857,134 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CBX8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351003
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.