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Gene: CTSD (cathepsin D) Homo sapiens
Symbol: CTSD
Name: cathepsin D
Description: Exhibits peptidase activity. Involved in several processes, including lipoprotein catabolic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and proteolysis. Localizes to endosome membrane; lysosomal membrane; and membrane raft. Implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin d (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311
Mus musculus (house mouse) : Ctsd (cathepsin D)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctsd (cathepsin D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsd (cathepsin D)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSD (cathepsin D)
Canis lupus familiaris (dog) : CTSD (cathepsin D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctsd (cathepsin D)
Sus scrofa (pig) : CTSD (cathepsin D)
Chlorocebus sabaeus (African green monkey) : CTSD (cathepsin D)
Heterocephalus glaber (naked mole-rat) : Ctsd (cathepsin D)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,752,755 - 1,764,573 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,752,755 - 1,763,927 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,773,982 - 1,785,222 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,730,561 - 1,741,798 (-)NCBINCBI36hg18NCBI36
Build 34111,730,560 - 1,741,798NCBI
Celera111,812,103 - 1,823,339 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,564,872 - 1,576,226 (-)NCBIHuRef
CHM1_1111,772,933 - 1,784,154 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CTSD
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351014
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.