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Gene: H1-5 (H1.5 linker histone, cluster member) Homo sapiens
Symbol: H1-5
Name: H1.5 linker histone, cluster member
Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H1; H1 histone family, member 5; H1.5; H1B; H1F5; H1s-3; HIST1H1B; histone 1, H1b; histone cluster 1 H1 family member b; histone cluster 1, H1b; histone H1.5; histone H1a; histone H1b; histone H1s-3; MGC126630; MGC126632
Mus musculus (house mouse) : Hist1h1b (histone cluster 1, H1b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hist1h1b (histone cluster 1 H1 family member b)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : H1-5 (H1.5 linker histone, cluster member)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100983953 (histone H1.5)
Canis lupus familiaris (dog) : H1-5 (H1.5 linker histone, cluster member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : H1-5 (H1.5 linker histone, cluster member)
Sus scrofa (pig) : H1-5 (H1.5 linker histone, cluster member)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38627,866,792 - 27,867,581 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37627,834,570 - 27,835,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36627,942,549 - 27,943,404 (-)NCBINCBI36hg18NCBI36
Build 34627,942,548 - 27,943,338NCBI
Celera629,440,606 - 29,441,461 (-)NCBI
Cytogenetic Map6p22.1NCBI
HuRef627,642,254 - 27,643,043 (-)NCBIHuRef
CHM1_1627,836,746 - 27,837,535 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on H1-5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351111
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.