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Gene: SERPINA7 (serpin family A member 7) Homo sapiens
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Symbol: SERPINA7
Name: serpin family A member 7
Description: There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ17820; mutant serpin family A member 7; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin A7; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; T4-binding globulin; TBG; TBGQTL; thyroxin-binding globulin; thyroxine-binding globulin
Orthologs:
Mus musculus (house mouse) : Serpina7 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : Serpina7 (serpin family A member 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpina7 (serpin family A member 7)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINA7 (serpin family A member 7)
Canis lupus familiaris (dog) : SERPINA7 (serpin family A member 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpina7 (serpin family A member 7)
Sus scrofa (pig) : SERPINA7 (serpin family A member 7)
more info ...
Related Pseudogenes: SERPINA7P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X106,032,439 - 106,038,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X105,277,190 - 105,282,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X105,163,853 - 105,167,722 (-)NCBINCBI36hg18NCBI36
Build 34X105,083,341 - 105,087,530NCBI
CeleraX105,751,759 - 105,757,289 (-)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX94,904,096 - 94,909,653 (-)NCBIHuRef
CHM1_1X105,188,486 - 105,194,014 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SERPINA7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351148
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.