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Gene: ZBTB33 (zinc finger and BTB domain containing 33) Homo sapiens
Symbol: ZBTB33
Name: zinc finger and BTB domain containing 33
Description: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: kaiso transcription factor; transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; zinc finger and BTB domain-containing protein 33; ZNF-kaiso; ZNF348
Mus musculus (house mouse) : Zbtb33 (zinc finger and BTB domain containing 33)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zbtb33 (zinc finger and BTB domain containing 33)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zbtb33 (zinc finger and BTB domain containing 33)
Pan paniscus (bonobo/pygmy chimpanzee) : ZBTB33 (zinc finger and BTB domain containing 33)
Canis lupus familiaris (dog) : ZBTB33 (zinc finger and BTB domain containing 33)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zbtb33 (zinc finger and BTB domain containing 33)
Sus scrofa (pig) : ZBTB33 (zinc finger and BTB domain containing 33)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X120,250,752 - 120,258,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,384,607 - 119,392,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,268,635 - 119,276,279 (+)NCBINCBI36hg18NCBI36
Build 34X119,166,488 - 119,174,133NCBI
CeleraX119,850,192 - 119,857,836 (+)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,837,055 - 108,844,699 (+)NCBIHuRef
CHM1_1X119,295,897 - 119,303,542 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ZBTB33
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351169
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.