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Gene: SPG21 (SPG21 abhydrolase domain containing, maspardin) Homo sapiens
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Symbol: SPG21
Name: SPG21 abhydrolase domain containing, maspardin
Description: Exhibits CD4 receptor binding activity. Predicted to be involved in antigen receptor-mediated signaling pathway. Localizes to the cytosol; intracellular membrane-bounded organelle; and trans-Golgi network transport vesicle. Implicated in Mast syndrome and hereditary spastic paraplegia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABHD21; acid cluster protein 33; ACP33; BM-019; GL010; maspardin; MAST; spastic paraplegia 21 (autosomal recessive, Mast syndrome); spastic paraplegia 21 autosomal recessive Mast syndrome protein; spastic paraplegia 21 protein; SPG21, maspardin
Orthologs:
Mus musculus (house mouse) : Spg21 (SPG21, maspardin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spg21 (SPG21 abhydrolase domain containing, maspardin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spg21 (SPG21 abhydrolase domain containing, maspardin)
Pan paniscus (bonobo/pygmy chimpanzee) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
Canis lupus familiaris (dog) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spg21 (SPG21 abhydrolase domain containing, maspardin)
Sus scrofa (pig) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,963,022 - 64,989,914 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371565,255,363 - 65,282,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,042,416 - 63,069,304 (-)NCBINCBI36hg18NCBI36
Build 341563,042,415 - 63,069,304NCBI
Celera1542,133,429 - 42,160,447 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1542,080,418 - 42,107,231 (-)NCBIHuRef
CHM1_11565,375,221 - 65,402,140 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SPG21
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351182
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.