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Analyze GeneStrainQTL List |
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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 6-propyl-2-thiouracil | decreases expression | ISO | RGD:1565373 | 6480464 | Propylthiouracil results in decreased expression of CLEC2L mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases expression | ISO | RGD:1565373 | 6480464 | Aflatoxin B1 results in increased expression of CLEC2L mRNA | CTD | PMID:23630614 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of CLEC2L polyA tail | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | RGD:1565373 | 6480464 | bisphenol A results in decreased expression of CLEC2L mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | RGD:1565373 | 6480464 | bisphenol A results in increased methylation of CLEC2L gene | CTD | PMID:28505145 | cadmium dichloride | increases expression | ISO | RGD:1565373 | 6480464 | Cadmium Chloride results in increased expression of CLEC2L mRNA | CTD | PMID:21297351 | dibutyl phthalate | decreases expression | ISO | RGD:1565373 | 6480464 | Dibutyl Phthalate results in decreased expression of CLEC2L mRNA | CTD | PMID:24893172 | dicrotophos | increases expression | EXP | | 6480464 | dicrotophos results in increased expression of CLEC2L mRNA | CTD | PMID:28302478 | ketamine | increases expression | ISO | RGD:1565373 | 6480464 | Ketamine results in increased expression of CLEC2L mRNA | CTD | PMID:20080153 | lead(0) | affects expression | EXP | | 6480464 | Lead affects the expression of CLEC2L mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | EXP | | 6480464 | Lead affects the expression of CLEC2L mRNA | CTD | PMID:28903495 | potassium dichromate | decreases expression | ISO | RGD:1609383 | 6480464 | Potassium Dichromate results in decreased expression of CLEC2L mRNA | CTD | PMID:23608068 | triclosan | decreases expression | EXP | | 6480464 | Triclosan results in decreased expression of CLEC2L mRNA | CTD | PMID:30510588 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of CLEC2L gene | CTD | PMID:29154799 | |
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CLEC2L (Homo sapiens - human) |
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Clec2l (Mus musculus - house mouse) |
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Clec2l (Rattus norvegicus - Norway rat) |
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CLEC2L (Pan paniscus - bonobo/pygmy chimpanzee) |
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CLEC2L (Canis lupus familiaris - dog) |
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Clec2l (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CLEC2L (Sus scrofa - pig) |
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RH47579 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_001080511 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001353368 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017011770 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC005531 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AK057548 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH236950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471070 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
HY072821 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
HY310314 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001080511 ⟹ NP_001073980 | |||||||||||||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | |||||||||||||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||||||||||||
Position: |
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Sequence: |
ATGGAGCCGGCCCGGGAGCCCCCCTCGCGGGCCCGGCCGCCGCCGCCCCTCGCCGCGCGCCCCGhide sequence |
RefSeq Acc Id: | NM_001353368 ⟹ NP_001340297 | |||||||||
RefSeq Status: | VALIDATED | |||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
ATGGAGCCGGCCCGGGAGCCCCCCTCGCGGGCCCGGCCGCCGCCGCCCCTCGCCGCGCGCCCCGhide sequence |
RefSeq Acc Id: | XM_017011770 ⟹ XP_016867259 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
CCCTCTCTGACCTTGGAGCGGGCTTCACGCTCTGAGCCTTCGTCTCCTCACGCATGAAGGGGAChide sequence |
Protein RefSeqs | NP_001073980 | (Get FASTA) | NCBI Sequence Viewer |
NP_001340297 | (Get FASTA) | NCBI Sequence Viewer | |
XP_016867259 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EAW83922 | (Get FASTA) | NCBI Sequence Viewer |
EAW83923 | (Get FASTA) | NCBI Sequence Viewer | |
P0C7M8 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001073980 ⟸ NM_001080511 |
- Peptide Label: | isoform 1 |
- UniProtKB: | P0C7M8 (UniProtKB/Swiss-Prot) |
- Sequence: |
MEPAREPPSRARPPPPLAARPAPAPAAPRPRSPAEAEARGPEGLLRRSGSGYEGSTSWKAALEDhide sequence |
RefSeq Acc Id: | XP_016867259 ⟸ XM_017011770 |
- Peptide Label: | isoform X1 |
- Sequence: |
MSILASKGCIKCEAPCPEDWLLYGRKCYFFSEEPRDWNTGRQYCHTHEAVLAVIQSQKELEFMFhide sequence |
RefSeq Acc Id: | NP_001340297 ⟸ NM_001353368 |
- Peptide Label: | isoform 2 |
- Sequence: |
MEPAREPPSRARPPPPLAARPAPAPAAPRPRSPAEAEARGPEGLLRRSGSGYEGSTSWKAALEAhide sequence |
Name | Type | Condition(s) | Position(s) | Clinical significance |
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 | copy number gain | Cleft palate, isolated [RCV000050876]|See cases [RCV000050876] | Chr7:129310166..159282390 [GRCh38] Chr7:128950007..159075079 [GRCh37] Chr7:128737243..158767840 [NCBI36] Chr7:7q32.1-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051101]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051101]|See cases [RCV000051101] | Chr7:132850196..159325876 [GRCh38] Chr7:132534956..159118566 [GRCh37] Chr7:132185496..158811327 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 | copy number loss | Ambiguous genitalia [RCV000052250]|See cases [RCV000052250] | Chr7:53985..159282531 [GRCh38] Chr7:53985..159075220 [GRCh37] Chr7:149068..158767981 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7q34(chr7:138795539-140364913)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053550]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053550]|See cases [RCV000053550] | Chr7:138795539..140364913 [GRCh38] Chr7:138480284..140064713 [GRCh37] Chr7:138130824..139711182 [NCBI36] Chr7:7q34 |
uncertain significance |
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 | copy number gain | Global developmental delay [RCV000053576]|See cases [RCV000053576] | Chr7:136309982..159307523 [GRCh38] Chr7:135994730..159100212 [GRCh37] Chr7:135645270..158792973 [NCBI36] Chr7:7q33-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 | copy number loss | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] | Chr7:132023155..149309794 [GRCh38] Chr7:131707914..149006885 [GRCh37] Chr7:131358454..148637818 [NCBI36] Chr7:7q32.3-36.1 |
pathogenic |
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 | copy number loss | Obesity [RCV000054173]|See cases [RCV000054173] | Chr7:135414108..144140219 [GRCh38] Chr7:135098857..143837312 [GRCh37] Chr7:134749397..143468245 [NCBI36] Chr7:7q33-35 |
pathogenic |
GRCh38/hg38 7q33-34(chr7:137741740-139688885)x1 | copy number loss | Cleft uvula [RCV000054174]|See cases [RCV000054174] | Chr7:137741740..139688885 [GRCh38] Chr7:137426486..139373631 [GRCh37] Chr7:137077026..139024171 [NCBI36] Chr7:7q33-34 |
pathogenic |
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 | copy number loss | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] | Chr7:139365967..159282531 [GRCh38] Chr7:139050713..159075220 [GRCh37] Chr7:138701253..158767981 [NCBI36] Chr7:7q34-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 | copy number gain | not provided [RCV000848126] | Chr7:10365..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 | copy number loss | See cases [RCV000135401] | Chr7:54185..159282390 [GRCh38] Chr7:54185..159075079 [GRCh37] Chr7:149268..158767840 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 | copy number gain | See cases [RCV000136592] | Chr7:137751200..154815582 [GRCh38] Chr7:137435946..154607292 [GRCh37] Chr7:137086486..154238225 [NCBI36] Chr7:7q33-36.2 |
pathogenic |
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 | copy number gain | See cases [RCV000136717] | Chr7:97419852..158923762 [GRCh38] Chr7:97049164..158716453 [GRCh37] Chr7:96887100..158409214 [NCBI36] Chr7:7q21.3-36.3 |
pathogenic |
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 | copy number loss | See cases [RCV000138120] | Chr7:134666829..158591882 [GRCh38] Chr7:134351581..158384574 [GRCh37] Chr7:134002121..158077335 [NCBI36] Chr7:7q33-36.3 |
pathogenic |
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 | copy number gain | See cases [RCV000138847] | Chr7:121863759..159335865 [GRCh38] Chr7:121503813..159128555 [GRCh37] Chr7:121291049..158821316 [NCBI36] Chr7:7q31.32-36.3 |
pathogenic |
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 | copy number loss | See cases [RCV000138903] | Chr7:135017687..148807400 [GRCh38] Chr7:134702438..148504492 [GRCh37] Chr7:134352978..148135425 [NCBI36] Chr7:7q33-36.1 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 | copy number gain | See cases [RCV000139654] | Chr7:132444095..159335866 [GRCh38] Chr7:132128854..159128556 [GRCh37] Chr7:131779394..158821317 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 | copy number gain | See cases [RCV000141413] | Chr7:115459015..159325817 [GRCh38] Chr7:115099069..159118507 [GRCh37] Chr7:114886305..158811268 [NCBI36] Chr7:7q31.2-36.3 |
pathogenic |
GRCh38/hg38 7q34(chr7:139476271-140449156)x1 | copy number loss | See cases [RCV000142350] | Chr7:139476271..140449156 [GRCh38] Chr7:139161017..140148956 [GRCh37] Chr7:138811557..139795425 [NCBI36] Chr7:7q34 |
uncertain significance |
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 | copy number gain | See cases [RCV000142802] | Chr7:131228764..159335866 [GRCh38] Chr7:130913523..159128556 [GRCh37] Chr7:130564063..158821317 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 | copy number gain | See cases [RCV000143754] | Chr7:131171478..159327017 [GRCh38] Chr7:130856237..159119707 [GRCh37] Chr7:130506777..158812468 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 | copy number gain | See cases [RCV000143707] | Chr7:132438072..159327017 [GRCh38] Chr7:132122831..159119707 [GRCh37] Chr7:131773371..158812468 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 | copy number loss | See cases [RCV000446044] | Chr7:43360..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) | copy number gain | not provided [RCV000767558] | Chr7:128312450..159119220 [GRCh37] Chr7:7q32.1-36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 | copy number gain | See cases [RCV000449264] | Chr7:137589621..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
TMEM106B-BRAF fusion | deletion | Pleomorphic xanthoastrocytoma [RCV000454357] | Chr7:12258147..140494267 [GRCh37] Chr7:7p21.3-q34 |
pathogenic |
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 | copy number gain | See cases [RCV000447709] | Chr7:98969247..159119707 [GRCh37] Chr7:7q22.1-36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 | copy number loss | See cases [RCV000448836] | Chr7:133799185..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 | copy number loss | See cases [RCV000447722] | Chr7:127295698..139524358 [GRCh37] Chr7:7q32.1-34 |
pathogenic |
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 | copy number gain | See cases [RCV000447956] | Chr7:128276078..159119707 [GRCh37] Chr7:7q32.1-36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 | copy number gain | See cases [RCV000510490] | Chr7:136758593..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) | copy number gain | See cases [RCV000510686] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 | copy number loss | See cases [RCV000511889] | Chr7:137917376..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 | copy number gain | See cases [RCV000511549] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q33-34(chr7:137434852-140349546)x3 | copy number gain | See cases [RCV000512176] | Chr7:137434852..140349546 [GRCh37] Chr7:7q33-34 |
uncertain significance |
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 | copy number gain | not provided [RCV000682911] | Chr7:98693388..159119707 [GRCh37] Chr7:7q22.1-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 | copy number gain | not provided [RCV000746278] | Chr7:10704..159122532 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
Single allele | complex | Renal transitional cell carcinoma [RCV000754611] | Chr7:129367205..140482957 [GRCh37] Chr7:7q32.2-34 |
likely pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 | copy number gain | not provided [RCV000746280] | Chr7:44935..159126310 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q34(chr7:139058803-139235826)x3 | copy number gain | not provided [RCV000747067] | Chr7:139058803..139235826 [GRCh37] Chr7:7q34 |
benign |
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 | copy number gain | not provided [RCV000849569] | Chr7:130592554..159119707 [GRCh37] Chr7:7q32.3-36.3 |
pathogenic |
Database | Acc Id | Source(s) |
AGR Gene | HGNC:21969 | AgrOrtholog |
COSMIC | CLEC2L | COSMIC |
Ensembl Genes | ENSG00000236279 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSP00000390661 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSP00000428508 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENST00000422142 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENST00000521281 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.10.100.10 | UniProtKB/Swiss-Prot |
GTEx | ENSG00000236279 | GTEx |
HGNC ID | HGNC:21969 | ENTREZGENE |
Human Proteome Map | CLEC2L | Human Proteome Map |
InterPro | C-type_lectin-like | UniProtKB/Swiss-Prot |
C-type_lectin-like/link_sf | UniProtKB/Swiss-Prot | |
CTDL_fold | UniProtKB/Swiss-Prot | |
NKR-like_CTLD | UniProtKB/Swiss-Prot | |
KEGG Report | hsa:154790 | UniProtKB/Swiss-Prot |
NCBI Gene | 154790 | ENTREZGENE |
Pfam | Lectin_C | UniProtKB/Swiss-Prot |
PharmGKB | PA142672101 | PharmGKB |
PROSITE | C_TYPE_LECTIN_1 | UniProtKB/Swiss-Prot |
C_TYPE_LECTIN_2 | UniProtKB/Swiss-Prot | |
SMART | CLECT | UniProtKB/Swiss-Prot |
Superfamily-SCOP | SSF56436 | UniProtKB/Swiss-Prot |
UniGene | Hs.57806 | ENTREZGENE |
UniProt | CLC2L_HUMAN | UniProtKB/Swiss-Prot |
H0YB20_HUMAN | UniProtKB/TrEMBL | |
P0C7M8 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2015-12-22 | CLEC2L | C-type lectin domain family 2 member L | C-type lectin domain family 2, member L | Symbol and/or name change | 5135510 | APPROVED |
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More on CLEC2L | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 1351189 |
Created: | 2005-03-08 |
Species: | Homo sapiens |
Last Modified: | 2019-11-26 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.