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Gene: NPPC (natriuretic peptide C) Homo sapiens
Symbol: NPPC
Name: natriuretic peptide C
Description: Exhibits hormone receptor binding activity. Involved in several processes, including cGMP biosynthetic process; negative regulation of oocyte maturation; and receptor guanylyl cyclase signaling pathway. Localizes to the protein-containing complex. Implicated in hypertension. Biomarker of arteriosclerosis; end stage renal failure; hypertension; and toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-type natriuretic peptide; CNP; CNP2; natriuretic peptide precursor C; natriuretic peptide precursor type C
Mus musculus (house mouse) : Nppc (natriuretic peptide type C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nppc (natriuretic peptide C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppc (natriuretic peptide C)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPC (natriuretic peptide C)
Canis lupus familiaris (dog) : NPPC (natriuretic peptide C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppc (natriuretic peptide C)
Sus scrofa (pig) : NPPC (natriuretic peptide C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2231,921,809 - 231,926,396 (-)Ensembl
GRCh382231,921,809 - 231,926,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,786,805 - 232,791,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,756 - 232,797,065 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NPPC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351265
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.