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Gene: HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8) Homo sapiens
Symbol: HSD17B8
Name: hydroxysteroid 17-beta dehydrogenase 8
Description: Exhibits NADH binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Localizes to mitochondrial matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; beta-ketoacyl-[acyl-carrier-protein] reductase-like; D6S2245E; dJ1033B10.9; estradiol 17-beta-dehydrogenase 8; estrogen 17-oxidoreductase; FABG; FABGL; H2-KE6; HKE6; hydroxysteroid (17-beta) dehydrogenase 8; KAR alpha subunit; ke-6; KE6; really interesting new gene 2 protein; RING2; SDR30C1; short chain dehydrogenase/reductase family 30C member 1; short chain dehydrogenase/reductase family 30C, member 1; testosterone 17-beta-dehydrogenase 8
Mus musculus (house mouse) : H2-Ke6 (H2-K region expressed gene 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Canis lupus familiaris (dog) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
Sus scrofa (pig) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Chlorocebus sabaeus (African green monkey) : HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)
Heterocephalus glaber (naked mole-rat) : Hsd17b8 (hydroxysteroid 17-beta dehydrogenase 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl633,204,655 - 33,206,831 (+)EnsemblGRCh38hg38GRCh38
GRCh38633,204,655 - 33,206,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,172,414 - 33,174,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,280,397 - 33,282,585 (+)NCBINCBI36hg18NCBI36
Build 34633,280,396 - 33,282,585NCBI
Celera634,726,785 - 34,728,973 (+)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,914,459 - 32,916,653 (+)NCBIHuRef
CHM1_1633,174,288 - 33,176,486 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSD17B8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351353
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.