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Gene: IRF8 (interferon regulatory factor 8) Homo sapiens
Symbol: IRF8
Name: interferon regulatory factor 8
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in cellular response to interferon-gamma; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Localizes to the cytoplasm and nucleoplasm. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; interferon consensus sequence-binding protein; IRF-8
Mus musculus (house mouse) : Irf8 (interferon regulatory factor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf8 (interferon regulatory factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf8 (interferon regulatory factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF8 (interferon regulatory factor 8)
Canis lupus familiaris (dog) : IRF8 (interferon regulatory factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf8 (interferon regulatory factor 8)
Sus scrofa (pig) : IRF8 (interferon regulatory factor 8)
Chlorocebus sabaeus (green monkey) : IRF8 (interferon regulatory factor 8)
Heterocephalus glaber (naked mole-rat) : Irf8 (interferon regulatory factor 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1685,899,162 - 85,922,606 (+)Ensembl
GRCh381685,899,162 - 85,922,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371685,932,774 - 85,956,212 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361684,490,275 - 84,513,713 (+)NCBINCBI36hg18NCBI36
Build 341684,490,274 - 84,513,710NCBI
Celera1670,235,758 - 70,259,207 (+)NCBI
Cytogenetic Map16q24.1NCBI
HuRef1671,673,680 - 71,697,160 (+)NCBIHuRef
CHM1_11687,344,316 - 87,367,790 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRF8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351360
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.